Abstract Let $R$ be a prime ring with its
Utumi ring of quotients $U$, $C=Z(U)$ extended centroid of $R$,
$F$ a nonzero generalized derivation of $R$, $L$ a noncentral
Lie ideal of $R$ and $k\geq 2$ a fixed integer. Suppose that there exists $0\neq a\in R$ such
that $a[F(u^{n_1}),u^{n_2},\ldots,u^{n_k}]=0$
for all $u \in L$, where $n_1, n_2, \ldots, n_k\geq 1$ are fixed
integers. Then either there exists $\lambda\in C$ such that $F(x)=\lambda
x$ for all $x\in R$, or $R$ satisfies $s_4$, the standard
identity in four variables.
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